Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy

作者: F Chang , J T Lee , P M Navolanic , L S Steelman , J G Shelton

DOI: 10.1038/SJ.LEU.2402824

关键词: PTENCell biologyBiologyCancer researchProtein kinase BMalignant transformationPI3K/AKT/mTOR pathwayNeoplastic transformationSignal transductionCarcinogenesisCell cycle

摘要: … that the PI3K/Akt pathway is a viable target for novel antineoplastic drugs. This review will describe PI3K/Akt pathway signaling and its effects on cell cycle progression, prevention of …

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