Novel thymidylate synthase enhancer region alleles in African populations.
作者： Sharon Marsh , Margaret M. Ameyaw , Jessie Githang'a , Anne Indalo , David Ofori-Adjei
DOI: 10.1002/1098-1004(200012)16:6<528::AID-HUMU11>3.0.CO;2-W
关键词: Allele frequency 、 Enhancer 、 Genetics 、 Biology 、 Tandem Repeat Sequence 、 Tandem repeat 、 Thymidylate synthase 、 Genotype 、 Polymorphism (computer science) 、 Allele
摘要: Thymidylate synthase (TS) regulates the production of DNA synthesis precursors and is an important target cancer chemotherapy. A polymorphic tandem repeat sequence in enhancer region TS promoter was previously described, where triple gives higher vitro gene expression than a double repeat. We recently identified ethnic differences allele frequencies between Caucasian Asian populations. now describe assessment genotype polymorphism 640 African (African American, Ghanaian Kenyan) (UK, USA) subjects. The were predominant alleles all populations studied. frequency similar Kenyan (49%), (56%), American (52%), (54%) British However, two novel contained 4 9 copies These found at (Kenyan 7%, 3%, 2%) Caucasians (UK 1%, USA 0%). this study decrease with Western migration, while common are relatively stable. This unique example suggesting influence multiple selection pressures within individual Hum Mutat 16:528, 2000.
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