Current promising treatment strategy for glioblastoma multiform: A review
作者： Sanjib Bahadur , Arvind Kumar Sahu , Pragya Baghel , Suman Saha
关键词: Internal medicine 、 Glioma 、 Chemotherapy 、 Temozolomide 、 Medicine 、 Oncology 、 Context (language use) 、 Targeted therapy 、 Survival rate 、 Treatment strategy 、 Glioblastoma
摘要: Glioblastoma multiform (GBM) is a heterogeneous group of primary neoplasm resistant to conventional therapies. Due their infiltrative nature it not fully isolated by aggressive surgery, radiation and chemotherapy showing poor prognosis in glioma patients. Unfortunately, diagnosed patients die within 1.5-2 year treatment schedule. Currently temozolomide (TMZ) the first choice for GBM TMZ metabolites methyl triazen imidazol carboxamide form complex with alkyl guanine transferase (O6 MGMT- DNA repair protein) induced damage following resistance properties inhibit overall survival Last few decades different conjugated strategy developed overcome enhance efficacy. The main aim this review introduce new promising pharmaceutical candidates that significantly influence therapeutic response context targeted therapy glioblastoma It hoped proposed are highly effective current limitations rate
oncologyreviews.org参考文章(35)
Yuan Yuan, Xue Xue, Ruo‐Bing Guo, Xiu‐Lan Sun, Gang Hu, Resveratrol enhances the antitumor effects of temozolomide in glioblastoma via ROS-dependent AMPK-TSC-mTOR signaling pathway. CNS Neuroscience & Therapeutics. ,vol. 18, pp. 536- 546 ,(2012) , 10.1111/J.1755-5949.2012.00319.X
ZE-SHUN ZHANG, JING WANG, YOU-BI SHEN, CHENG-CHENG GUO, KE SAI, FU-RONG CHEN, XIN MEI, FU HAN, ZHONG-PING CHEN, Dihydroartemisinin increases temozolomide efficacy in glioma cells by inducing autophagy. Oncology Letters. ,vol. 10, pp. 379- 383 ,(2015) , 10.3892/OL.2015.3183
Zhihua Chen, Xianliang Lai, Shuxin Song, Xingen Zhu, Jianming Zhu, Nanostructured lipid carriers based temozolomide and gene co-encapsulated nanomedicine for gliomatosis cerebri combination therapy Drug Delivery. ,vol. 23, pp. 1369- 1373 ,(2016) , 10.3109/10717544.2015.1038857
Huile Gao, Zhi Yang, Shuang Zhang, Shijie Cao, Shun Shen, Zhiqing Pang, Xinguo Jiang, Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization Scientific Reports. ,vol. 3, pp. 2534- 2534 ,(2013) , 10.1038/SREP02534
Chang Xia, Roberto Leon-Ferre, Douglas Laux, Jeremy Deutsch, Brian J. Smith, Melanie Frees, Mohammed Milhem, Treatment of resistant metastatic melanoma using sequential epigenetic therapy (decitabine and panobinostat) combined with chemotherapy (temozolomide) Cancer Chemotherapy and Pharmacology. ,vol. 74, pp. 691- 697 ,(2014) , 10.1007/S00280-014-2501-1
Anamaria Orza, Soriţău, Florea, Pana, Bratu, Pal, Florian, Daniel Casciano, Tomuleasa, Olenic, Biris, Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles. International Journal of Nanomedicine. ,vol. 8, pp. 689- 702 ,(2013) , 10.2147/IJN.S37481
V Martín, Ana María Sanchez-Sanchez, F Herrera, Candelaria Gomez-Manzano, J Fueyo, Marco Antonio Alvarez-Vega, I Antolín, C Rodriguez, None, Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells British Journal of Cancer. ,vol. 108, pp. 2005- 2012 ,(2013) , 10.1038/BJC.2013.188
M. Figul, A. S�ling, H. J. Dong, T.-C. Chou, N. G. Rainov, Combined effects of temozolomide and the ribonucleotide reductase inhibitors didox and trimidox in malignant brain tumor cells Cancer Chemotherapy and Pharmacology. ,vol. 52, pp. 41- 46 ,(2003) , 10.1007/S00280-003-0611-2
Patrick T. Grogan, Jann N. Sarkaria, Barbara N. Timmermann, Mark S. Cohen, Oxidative cytotoxic agent withaferin A resensitizes temozolomide-resistant glioblastomas via MGMT depletion and induces apoptosis through Akt/mTOR pathway inhibitory modulation Investigational New Drugs. ,vol. 32, pp. 604- 617 ,(2014) , 10.1007/S10637-014-0084-7
Abdel Nasser Hosein, Yi Chieh Lim, Bryan Day, Brett Stringer, Stephen Rose, Richard Head, Leah Cosgrove, Peter Sminia, Michael Fay, Jennifer H Martin, None, The effect of valproic acid in combination with irradiation and temozolomide on primary human glioblastoma cells Journal of Neuro-oncology. ,vol. 122, pp. 263- 271 ,(2015) , 10.1007/S11060-014-1713-X