Enhanced monocyte chemoattractant protein-3/CC chemokine ligand-7 in usual interstitial pneumonia.

摘要: Chemokines are increased and may exert effects on both inflammatory remodeling events in idiopathic pulmonary pneumonia (IIP). Accordingly, we examined the concomitant expression of CC chemotactic cytokines or chemokines their corresponding receptors surgical lung biopsies obtained at time disease diagnosis fibroblasts grown from these biopsies. By gene array analysis, upper lower lobe primary fibroblast lines patients with usual interstitial (UIP), nonspecific pneumonia, respiratory bronchiolitis-interstitial disease, but not without IIP, exhibited CCL7 expression. TAQMAN, immunohistochemical, ELISA analyses confirmed that was expressed significantly higher levels UIP compared IIP. Higher were present cultures IIP non-IIP fibroblasts, CCL5, a CCR5 agonist, synthesis by fibroblasts. Together, data suggest is highly relative to other this chemokine have major role progression fibrosis patient group.