Fine-needle aspiration cytology of triple-negative basal-like breast cancer
作者： Shizuka Akashi , Hiroko Kuwabara , Yoshitaka Kurisu , Yuko Takahashi , Emi Yasuda
DOI: 10.1002/DC.21807
关键词: Metaplastic carcinoma 、 Squamous metaplasia 、 Pathology 、 Carcinoma 、 Mitotic index 、 Breast cancer 、 Cytology 、 Medullary carcinoma 、 Biology 、 Pleomorphism (cytology)
摘要: Invasive breast cancer is divided into luminal A, B, HER2 overexpression, basal-like (BL) and normal-like subtypes, among which the BL subtype has worst prognosis. The purpose of this study was to determine clinicopathological cytological characteristics (BLBC). Fine-needle aspiration cytology samples from 17 patients with consecutive BLBC were investigated, findings compared those other subtypes (10 cases each) for following cytomorphological features: necrosis; lymphocyte infiltration; mitotic index; apoptosis; naked nuclei; nuclear/cytoplasmic ratio; nuclear margin, size pleomorphism; chromatin granularity density; nucleolar appearance. Histologically, BLBCs heterogeneous, included medullary carcinoma metaplastic carcinoma, in addition invasive ductal carcinoma. Cytologically, high index, nuclei, irregular margin significantly observed when both A B subtypes. Large nuclei nucleoli infiltration frequently seen respectively. Squamous nodules all cases, but not overexpression subtype. Lymphocyte infiltration, squamous metaplasia, such as a or large an presence nucleoli, may be clues indicating BLBC. Diagn. Cytopathol. 2013;41:283–287. © 2011 Wiley Periodicals, Inc.
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