Expression and localization of laminin 5, laminin 10, type IV collagen, and amelotin in adult murine gingiva.
作者： Takashi Sawada , Takaki Yamazaki , Kazuko Shibayama , Kaido Kumazawa , Yoko Yamaguchi
DOI: 10.1007/S10735-013-9559-7
关键词: Type IV collagen 、 Chemistry 、 Laminin 、 Ameloblast 、 Pathology 、 Tooth enamel 、 In situ hybridization 、 Immunohistochemistry 、 Junctional epithelium 、 Cell biology 、 Basal lamina
摘要: The biochemical composition of the internal and external basal laminae in junctional epithelium differs significantly, precise cellular origin their respective molecules remains to be determined. In present study, expression localization three basement membrane-specific molecules—laminin 5 (γ2 chain), type IV collagen (α1 laminin 10 (α5 chain)—and one tooth-specific molecule, amelotin, was analyzed adult murine gingiva by using situ hybridization immunohistochemistry. results showed that outermost cells facing tooth enamel strongly expressed mRNA, supporting immunohistochemical staining data. This suggests is actively synthesized epithelial products are incorporated into lamina maintain firm adhesion throughout life. Conversely, no amelotin mRNA signals were detected cells, suggesting localized on mainly derived from maturation-stage ameloblasts. Weak sporadic addition indicates these undergo turnover less frequently animals.
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