Reversible Tumorigenesis by MYC in Hematopoietic Lineages

摘要: The targeted repair of mutant protooncogenes or the inactivation their gene products may be a specific and effective therapy for human neoplasia. To examine this possibility, we have used tetracycline regulatory system to generate transgenic mice that conditionally express MYC protooncogene in hematopoietic cells. Sustained expression transgene culminated formation malignant T cell lymphomas acute myleoid leukemias. subsequent caused regression established tumors. Tumor was associated with rapid proliferative arrest, differentiation apoptosis tumor cells, resumption normal host hematopoiesis. We conclude even though tumorigenesis is multistep process, remediation single genetic lesion sufficient reverse malignancy.