Cetuximab in Previously Treated Colorectal Cancer
作者： Naureen Starling , David Cunningham
关键词: Irinotecan 、 Epidermal growth factor receptor 、 Internal medicine 、 Cetuximab 、 Oncology 、 Colorectal cancer 、 Disease 、 Medicine 、 Oxaliplatin 、 Previously treated 、 Targeted therapy
摘要: Within the past decade, there have been considerable advances in first- and second-line treatment of colorectal cancer (CRC). For many years, 5-fluorouracil was only therapeutic option for first-line CRC, virtually no effective salvage therapies were available. However, advent oxaliplatin irinotecan has improved outcomes advanced providing increased choice setting therapies. Many patients are now receiving multiple lines therapy, it is previously treated CRC that cetuximab, a monoclonal antibody to epidermal growth factor receptor, successfully developed based on sound scientific principles. The ability integrate new biologic with conventional cytotoxic agents marks era this disease. This review discusses development cetuximab pretreated date future directions novel therapy.
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Zhen Fan, Hideo Masui, John Mendelsohn, Jose Baselga, Antitumor Effect of Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies plus cis-Diamminedichloroplatinum on Well Established A431 Cell Xenografts Cancer Research. ,vol. 53, pp. 4637- 4642 ,(1993)
J. Baselga, D. Pfister, M.R. Cooper, R. Cohen, B. Burtness, M. Bos, G. D’Andrea, A. Seidman, L. Norton, K. Gunnett, J. Falcey, V. Anderson, H. Waksal, J. Mendelsohn, Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin Journal of Clinical Oncology. ,vol. 18, pp. 904- 914 ,(2000) , 10.1200/JCO.2000.18.4.904
W. Zhang, J. Yun, O. A. Press, M. Gordon, D. Y. Yang, N. Mallik, A. Sherrod, S. Iqbal, H. J. Lenz, Association of Cyclin D1 (CCND1) gene A870G polymorphism and clinical outcome of EGFR-positive metastatic colorectal cancer patients treated with epidermal growth factor receptor (EGFR) inhibitor cetuximab (C225) Journal of Clinical Oncology. ,vol. 22, pp. 3518- 3518 ,(2004) , 10.1200/JCO.2004.22.90140.3518
Yosef Yarden, Mark X. Sliwkowski, Untangling the ErbB signalling network Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 127- 137 ,(2001) , 10.1038/35052073
Irena Porębska, Antonina Harłozińska, Tomasz Bojarowski, Expression of the tyrosine kinase activity growth factor receptors (EGFR, ERB B2, ERB B3) in colorectal adenocarcinomas and adenomas. Tumor Biology. ,vol. 21, pp. 105- 115 ,(2000) , 10.1159/000030116
Astrid Mayer, Masafumi Takimoto, Elke Fritz, Georgine Schellander, Klaus Kofler, Heinz Ludwig, The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer Cancer. ,vol. 71, pp. 2454- 2460 ,(1993) , 10.1002/1097-0142(19930415)71:8<2454::AID-CNCR2820710805>3.0.CO;2-2
Christoph A Ritter, Carlos L Arteaga, The epidermal growth factor receptor–tyrosine kinase: A promising therapeutic target in solid tumors Seminars in Oncology. ,vol. 30, pp. 3- 11 ,(2003) , 10.1053/SONC.2003.50027
John Mendelsohn, Jose Baselga, Status of Epidermal Growth Factor Receptor Antagonists in the Biology and Treatment of Cancer Journal of Clinical Oncology. ,vol. 21, pp. 2787- 2799 ,(2003) , 10.1200/JCO.2003.01.504
Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella, Sarada Gurubhagavatula, Ross A. Okimoto, Brian W. Brannigan, Patricia L. Harris, Sara M. Haserlat, Jeffrey G. Supko, Frank G. Haluska, David N. Louis, David C. Christiani, Jeff Settleman, Daniel A. Haber, Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib The New England Journal of Medicine. ,vol. 350, pp. 2129- 2139 ,(2004) , 10.1056/NEJMOA040938
Hideo Ogiso, Ryuichiro Ishitani, Osamu Nureki, Shuya Fukai, Mari Yamanaka, Jae-Hoon Kim, Kazuki Saito, Ayako Sakamoto, Mio Inoue, Mikako Shirouzu, Shigeyuki Yokoyama, Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains. Cell. ,vol. 110, pp. 775- 787 ,(2002) , 10.1016/S0092-8674(02)00963-7