Hotspot mutations in common oncogenes are infrequent in nasopharyngeal carcinoma

摘要: Oncogene mutations contribute to carcinogenesis and can provide potential therapeutic targets for clinical anticancer management. However, oncogene mutation patterns in nasopharyngeal carcinoma (NPC) have yet be fully elucidated. To gain insight into NPC, a high-throughput OncoCarta panel assay was used determine 238 hotspot across 19 common oncogenes 8 NPC cell lines 160 patient samples from southern China. Statistical analyses were further conducted identify associations between selected clinicopathological characteristics. In total, we identified 24 11 17 (10.6%) patients. Four patients exhibited at least one oncogene. We also PIK3CA H1047R mutant 7 lines. addition, showed no correlation with either risk habits (smoking drinking) or other characteristics except TNM stage. KIT associated poorer overall relapse-free survival. Furthermore, together age N stage independent prognostic factors NPC. Taken together, the present study is first report on multiple found that are infrequent The lack of requires comprehensive characterization gene developing new future.