The investigation of the interaction between Oxymetazoline hydrochloride and mucin by spectroscopic approaches.
作者： Xianyong Yu , Heting Liu , Ying Yang , Shiyu Lu , Qin Yao
DOI: 10.1016/J.SAA.2012.11.019
关键词: Hydrogen bond 、 Physical chemistry 、 Oxymetazoline Hydrochloride 、 Fluorescence spectroscopy 、 Nasal decongestant 、 Ultraviolet visible spectroscopy 、 Chemistry 、 Analytical chemistry 、 Fluorescence 、 Quenching (fluorescence) 、 van der Waals force
摘要: The fluorescence and ultraviolet spectroscopy were explored to study the interaction between Oxymetazoline hydrochloride (OMZH) mucin under imitated physiological condition. results demonstrated that quenching mechanism OMZH is a combined process. binding constants (K(a)), sites (n) corresponding thermodynamic parameters (ΔG, ΔH, ΔS) of system calculated at different temperatures. hydrogen bonds van der Waals forces play major role in mucin. According Forster non-radiation energy transfer theory, distance was calculated.
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