Molecular pathogenesis of malignant gliomas.

作者: B. K. Ahmed Rasheed , Rodney N. Wiltshire , Sandra H. Bigner , Darell D. Bigner

DOI: 10.1097/00001622-199905000-00004

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摘要: De novo glioblastomas develop in older patients without prior clinical history of less malignant tumors. Progressive are common among younger and arise through progression from lower-grade astrocytomas. CDKN2A deletions, PTEN alterations, EGFR amplification more preval

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