Roles of cell fusion, hybridization and polyploid cell formation in cancer metastasis.

摘要: Cell-cell fusion is a normal biological process playing essential roles in organ formation and tissue differentiation, repair regeneration. Through cell somatic cells undergo rapid nuclear reprogramming epigenetic modifications to form hybrid with new genetic phenotypic properties at rate exceeding that achievable by random mutations. Factors stimulate are inflammation hypoxia. Fusion of cancer non-neoplastic facilitates several malignancy-related phenotypes, e.g., into induced pluripotent stem epithelial mesenchymal transition. There now considerable vitro, vivo clinical evidence motile leucocytes such as macrophages plays major role metastasis. Of the many changes after hybridizing leucocytes, it notable hybrids acquire resistance chemo- radiation therapy. One phenomenon has been largely overlooked yet these processes polyploidization. Regardless mechanism polyploid formation, happens response genotoxic stresses enhances cell's ability survive. Here we summarize recent progress research focus on an important for In addition, discuss importance polyploidization solid tumors.