Loss of a Harvey ras allele in sporadic Wilms' tumour
作者： Anthony E. Reeve , Philip J. Housiaux , Robert J. M. Gardner , Wendy E. Chewings , Roseanne M. Grindley
DOI: 10.1038/309174A0
关键词:
摘要: Genomic changes within chromosome band 11p13 appear to have a role in the initiation of Wilms' tumour1–7. The human Harvey ras oncogene, c-Ha-ras1, has been located by Jhanwar et al.8 immediately adjacent this region at 11p14.1, although several groups assigned gene more distally 11p15 (refs 9–11). We examined tumour DNA from two cases sporadic tumour, and report here that both one constitutional c-Ha-ras1 alleles was absent. One had reciprocal translocation between short arm 11 (at 11p13), long 12, with no visible loss chromosomal material. allele association indicates submicroscopic deletion occurred. resulting hemizygosity may initiation. Our results indicate ‘Wilms' locus’ be close proximity. It would, therefore, premature exclude possibility these sites are functionally related.
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