Resequencing Analysis of the Human Tyrosine Kinase Gene Family in Pancreatic Cancer
作者： Takashi Kubo , Yukie Kuroda , Akiko Kokubu , Fumie Hosoda , Yasuhito Arai
DOI: 10.1097/MPA.0B013E3181B8FEB0
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摘要: Objectives: Pancreatic cancer is one of the most intractable cancers. However, comprehensive view somatic mutations in this tumor far from clear. The tyrosine kinase (TK) gene family, which encodes important regulators various signal transduction pathways, frequently altered families human cancer. Methods: To clarify mutation profile TKs pancreatic cancer, we performed a systematic screening domains all TK genes (636 exons 90 total) 11 cell lines and 29 microdissected primary tumors. Results: We identified 15 nonsynonymous alterations that included 9 DNA 6 In particular, previously reported pathogenic NTRK3 KRAS/BRAF wild-type 2 Src family kinases (YES1 LYN) would be expected to cause structural changes. Conclusions: Our genome-wide resequencing approach revealed novel oncogenic pathways
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