Pemetrexed in the treatment of malignant mesothelioma: results from an expanded access program in Germany.
作者： Martin Reck , Rolf A. Stahel , Joachim von Pawel , Meinolf Karthaus , Soenke Korfee
DOI: 10.1016/J.RMED.2009.07.019
关键词:
摘要: An international expanded access program was initiated to provide treatment with pemetrexed prior registration and reimbursement for malignant mesothelioma (MM). Chemonaive pretreated patients inoperable MM of the pleura or peritoneum were eligible. This report describes results obtained in German centers. Investigators could choose between three treatments: Pemetrexed 500 mg/m(2) alone (P) combination cisplatin 75 (PC) carboplatin AUC 5 (PCb). From November 2002 June 2004, a total 567 (554 pleural MM; 41% pretreated) included. Of 548 evaluable MM, 191 received P, 137 PC 220 PCb. Patients P group more often (70%) had worse performance status compared other groups. In PC, PCb groups overall response rate (ORR) 16%, 24% 18%, median time progression (TTP) 5.5, 8.2, 6.9 months, survival (OS) 8.7, 11.3 9.7 months respectively. Efficacy outcomes better chemonaive than patients, less hematotoxic Treatment platinum safe active as first second-line therapy.
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Jens Benn Sørensen, Stein Sundstrøm, Katharina Perell, Anne-Kathrine Thielsen, Pemetrexed as Second-Line Treatment in Malignant Pleural Mesothelioma after Platinum-Based First-Line Treatment Journal of Thoracic Oncology. ,vol. 2, pp. 147- 152 ,(2007) , 10.1097/JTO.0B013E31802F3813
Brian Morris, Mohammed Al-Qahtani, Shaheenah Dawood, Ronald Onerheim, Malignant mesothelioma of the tunica vaginalis. Canadian Journal of Urology. ,vol. 14, pp. 3514- ,(2007)
R. Thödtmann, H. Depenbrock, H. Dumez, J. Blatter, R. D. Johnson, A. van Oosterom, A.-R. Hanauske, Clinical and Pharmacokinetic Phase I Study of Multitargeted Antifolate (LY231514) in Combination With Cisplatin Journal of Clinical Oncology. ,vol. 17, pp. 3009- 3016 ,(1999) , 10.1200/JCO.1999.17.10.3009
C Pelucchi, M Malvezzi, C La Vecchia, F Levi, A Decarli, E Negri, The Mesothelioma epidemic in Western Europe: An update British Journal of Cancer. ,vol. 90, pp. 1022- 1024 ,(2004) , 10.1038/SJ.BJC.6601638
Armando Santoro, Mary E. O'Brien, Rolf A. Stahel, Kristiaan Nackaerts, Paul Baas, Meinolf Karthaus, Wilfried Eberhardt, Luis Paz-Ares, Stein Sundstrom, Yushan Liu, Veronique Ripoche, Johannes Blatter, Carla M. Visseren-Grul, Christian Manegold, Pemetrexed Plus Cisplatin or Pemetrexed Plus Carboplatin for Chemonaïve Patients with Malignant Pleural Mesothelioma: Results of the International Expanded Access Program Journal of Thoracic Oncology. ,vol. 3, pp. 756- 763 ,(2008) , 10.1097/JTO.0B013E31817C73D6
Graham Dark, Maurizio Marangolo, Giorgio V. Scagliotti, Rob J. van Klaveren, Roberto Labianca, Monika Serke, W Schuette, Jan P. van Meerbeeck, David Heigener, Yushan Liu, Susumu Adachi, Johannes Blatter, Joachim von Pawel, Paul Taylor, Bruno Castagneto, Single-Agent Pemetrexed for Chemonaïve and Pretreated Patients with Malignant Pleural Mesothelioma: Results of an International Expanded Access Program Journal of Thoracic Oncology. ,vol. 3, pp. 764- 771 ,(2008) , 10.1097/JTO.0B013E31817C73EC
Pasi A. Jänne, Antoinette J. Wozniak, Chandra P. Belani, Mary-Louise Keohan, Helen J. Ross, Jonathan A. Polikoff, David M. Mintzer, Zhishen Ye, Matthew J. Monberg, Coleman K. Obasaju, Pemetrexed Alone or in Combination with Cisplatin in Previously Treated Malignant Pleural Mesothelioma: Outcomes from a Phase IIIB Expanded Access Program Journal of Thoracic Oncology. ,vol. 1, pp. 506- 512 ,(2006) , 10.1016/S1556-0864(15)30351-8
P.H. Sugarbaker, T.D. Yan, O.A. Stuart, D. Yoo, Comprehensive management of diffuse malignant peritoneal mesothelioma Ejso. ,vol. 32, pp. 686- 691 ,(2006) , 10.1016/J.EJSO.2006.03.012
J. C. Wagner, C. A. Sleggs, P. Marchand, Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province. Occupational and Environmental Medicine. ,vol. 17, pp. 260- 271 ,(1960) , 10.1136/OEM.17.4.260
Kamal E. Bani-Hani, Kamal A. Gharaibeh, Malignant peritoneal mesothelioma Journal of Surgical Oncology. ,vol. 91, pp. 17- 25 ,(2005) , 10.1002/JSO.20266