Impact of EGFR expression on colorectal cancer patient prognosis and survival

摘要: 1Departement d'Oncologie Medicale, Hopital Pitie-Salpetriere, Paris; 2Departement d'Anatomopathologie, Avicenne, Bobigny; 3 Departement de Radiotherapie et Statistique, Europeen Georges Pompidou, 4 d'Oncopharmacologie, Centre Antoine Lacassagne, Nice; 5 Gastro-Enterologie, 6 Chirurgie Viscerale, Bobigny, 7 8 d'Hematobiologie, 9 Biochimie Biologie Moleculaire, 10 Anticancereux, Clermont-Ferrand, France Background: Epidermal growth factor receptor (EGFR) is overexpressed in many types of cancers, especially colorectal cancer (CRC), and seems to reflect more aggressive histological clinical behaviors. The aim this study was evaluate EGFR immunohistochemical reactivity CRC biopsies, analyze its relationship with various characteristics survival. Patients methods: A composite score, obtained by multiplying the grade (% positive cells) intensity labeling (0-9) used define patients low or high expression whose clinicopathological features were then compared. Univariate tests multivariate Cox proportional hazards model applied for data analysis. Results: Tissue sections from 150 a median follow-up 40 months examined. Median patient age at diagnosis 70 years (range 38-89 years). 143 (97%) 118 (80%). According analysis, overexpression significantly associated tumor stage, higher percentage T3 than T4 (P=0.003) not overall Conclusions: population TNM (tumor-node-metastasis) stage T3. In context new therapeutic strategy using EGFR-targeted therapies, although remains controversial prognostic factor, expression-stage association may play crucial role decision initiate an adjuvant treatment.