Histamine H4 receptor ligands and their potential therapeutic applications: an update.
作者： Róbert Kiss , György M Keserű
DOI: 10.1517/13543776.2012.665447
关键词:
摘要: Introduction: Several studies underlined the critical role of histamine H4 receptor (H4R) in inflammation, thus modulators have been suggested as promising drug candidates inflammatory diseases. First ligands typically indole or amino-pyrimidine scaffolds. During last few years, however, serious efforts made to identify novel chemotypes with improved pharmacodynamic and pharmacokinetic properties. Areas covered: covered this review include an overview on published scientific papers, well patent applications between 2009 2011. Recently discovered scaffolds possessing significant activity were analyzed their therapeutic potential was reviewed. Expert opinion: Recent results from literature reinforce major H4R diseases such pruritus, asthma, pain allergic rhinitis. Novel suggest further indications cancer, neuropathi...
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