All things must pass: contrasts and commonalities in eukaryotic and bacterial mRNA decay

摘要: Despite its universal importance for controlling gene expression, mRNA degradation was initially thought to occur by disparate mechanisms in eukaryotes and bacteria. This conclusion based on differences the structures used these organisms protect termini RNases modifying enzymes originally implicated decay. Subsequent discoveries have identified several striking parallels between cellular factors molecular events that govern two kingdoms of life. Nevertheless, some key distinctions remain, most fundamental which may be related different bacteria control translation initiation.