Immunoglobulin G Fragment C Receptor Polymorphisms and Clinical Efficacy of Trastuzumab-Based Therapy in Patients With HER-2/neu–Positive Metastatic Breast Cancer
作者： Antonino Musolino , Nadia Naldi , Beatrice Bortesi , Debora Pezzuolo , Marzia Capelletti
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摘要: Purpose The anti–HER-2/neu monoclonal antibody trastuzumab has been shown to engage both activatory (fragment C receptor [FcγR]IIIa; FcγRIIa) and inhibitory (FcγRIIb) receptors FcγR polymorphisms have identified that may affect the antibody-dependent cell-mediated cytotoxicity (ADCC) of natural-killer cells/monocytes. In this study, we tested whether are associated with clinical outcome patients breast cancer who received trastuzumab. Patients Methods Fifty-four consecutive HER-2/neu–amplified receiving plus taxane for metastatic disease were evaluated genotype FcγRIIIa-158 valine(V)/phenylalanine(F), FcγRIIa-131 histidine(H)/arginine(R), FcγRIIb-232 isoleucine(I)/threonine(T) polymorphisms. Trastuzumab-mediated ADCC patients' peripheral blood mononuclear cells (PBMCs) was measured by chromium-51 release using a HER-2/neu–expressing human cell line as target. Controls comprised thirt...
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nlm.it 参考文章(35)
Josée Golay, Luisella Zaffaroni, Thomas Vaccari, Manuela Lazzari, Gian-Maria Borleri, Sergio Bernasconi, Francesco Tedesco, Alessandro Rambaldi, Martino Introna, Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis Blood. ,vol. 95, pp. 3900- 3908 ,(2000) , 10.1182/BLOOD.V95.12.3900
Thomas Lehrnbecher, Charles B. Foster, Shaoxian Zhu, Susan F. Leitman, Lynn R. Goldin, Konrad Huppi, Stephen J. Chanock, Variant Genotypes of the Low-Affinity Fcγ Receptors in Two Control Populations and a Review of Low-Affinity Fcγ Receptor Polymorphisms in Control and Disease Populations Blood. ,vol. 94, pp. 4220- 4232 ,(1999) , 10.1182/BLOOD.V94.12.4220
Robert L Shields, Angela K Namenuk, Kyu Hong, Y Gloria Meng, Julie Rae, John Briggs, Dong Xie, Jadine Lai, Andrew Stadlen, Betty Li, Judith A Fox, Leonard G Presta, None, High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR Journal of Biological Chemistry. ,vol. 276, pp. 6591- 6604 ,(2001) , 10.1074/JBC.M009483200
David R. Cox, Regression Models and Life-Tables Springer Series in Statistics. ,vol. 34, pp. 527- 541 ,(1992) , 10.1007/978-1-4612-4380-9_37
Ann W Morgan, Jennifer H Barrett, Bridget Griffiths, Deepak Subramanian, Jim I Robinson, Viki H Keyte, Manir Ali, Elizabeth A Jones, Robert W Old, Frederique Ponchel, Arthur W Boylston, R Deva Situnayake, Alexander F Markham, Paul Emery, John D Isaacs, None, Analysis of Fcγ receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B Arthritis Research & Therapy. ,vol. 8, pp. 1- 9 ,(2005) , 10.1186/AR1847
P. A. M. Warmerdam, N. A. C. Westerdaal, A. Vlug, J. G. J. Van De Winkel, P. J. A. Capel, A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding. Journal of Immunology. ,vol. 147, pp. 1338- 1343 ,(1991)
Wen-Kai Weng, Ronald Levy, Two Immunoglobulin G Fragment C Receptor Polymorphisms Independently Predict Response to Rituximab in Patients With Follicular Lymphoma Journal of Clinical Oncology. ,vol. 21, pp. 3940- 3947 ,(2003) , 10.1200/JCO.2003.05.013
Chieko Kyogoku, Hilde M. Dijstelbloem, Naoyuki Tsuchiya, Yoko Hatta, Hitoshi Kato, Akihiro Yamaguchi, Toru Fukazawa, Marc D. Jansen, Hiroshi Hashimoto, Jan G. J. van de Winkel, Cees G. M. Kallenberg, Katsushi Tokunaga, Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility. Arthritis & Rheumatism. ,vol. 46, pp. 1242- 1254 ,(2002) , 10.1002/ART.10257
J. E. Gessner, H. Heiken, A. Tamm, R. E. Schmidt, The IgG Fc receptor family Annals of Hematology. ,vol. 76, pp. 231- 248 ,(1998) , 10.1007/S002770050396
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25