SIMS ion microscopy as a novel, practical tool for subcellular chemical imaging in cancer research

摘要: The development of cryogenic sample preparations, subcellular image quantification schemes, and correlative confocal laser scanning microscopy ion have made dynamic SIMS a versatile tool in biology medicine. For example, can provide much needed, novel information on calcium influx intracellular stores at organelle resolution normal transformed cells order to better understand the altered signaling malignant cells. 3-D imaging revealed gradients undergoing mitosis cytokinesis. Studies localization anticancer drugs is another area research where observations many types cancers. Ion already an essential boron neutron capture therapy (BNCT) brain cancer as it be used quantitatively location tissues. This critically needed for testing efficacy boronated agents calculations radiation dosimetry.