The pharmacological profile of ovalbumin-induced paw oedema in rats.

摘要: Rats are commonly used in anaphylaxis models, mainly intestinal anaphylaxis. Hypersensitivity mechanisms complex and they not clearly defined. Ovalbumin (OVA) is for studies on the hypersensitivity mechanism. However, potential pro-inflammatory mediators induced by this antigen model of paw oedema immunized rats still completely understood. This work examines pharmacological modulation several involved rat hind immune OVA. Wistar were previously (14-18 days) with OVA (30 μg, intraperitoneally) or sham-sensitized aluminum hydroxide (control). The volumes measured before antigenic stimuli 1, 2, 3 4 h after intraplantar injection (10 μg/paw). Subcutaneous dexamethasone, diphenhydramine, cyproheptadine, chlorpromazine methysergide significantly inhibited (pl0.05) allergic oedema. dual inhibitor cyclooxygenase lipoxygenase (NDGA), (indomethacin), (MK-886), PAF antagonist (WEB 2086), mast cell stabilizer (ketotifen), anti-histamine (meclizine) did inhibit In addition, thalidomide pentoxifylline (anti-tumour necrosis factor drugs) ineffective against OVA-induced fact that indomethacin, MK-886, NDGA WEB 2086 unable to indicates dexamethasone action seems be via phospholipase A2, but possibly due synthesis and/or inhibitory activity cytokines. inhibition meclizine, may suggest a different mechanism, which independent effect histamine. These data indicate more sensitive anti-serotonin drugs, anti-5-HT2, suggesting principal mediator inflammatory response serotonin.