Hormonal and Cell-specific Regulation of the Human Growth Hormone and Chorionic Somatomammotropin Genes
作者： Norman L. Eberhardt , Shi-Wen Jiang , Allan R. Shepard , Andrew M. Arnold , Miguel A. Trujillo
DOI: 10.1016/S0079-6603(08)60362-1
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摘要: Publisher Summary This chapter focuses on the hormonal and cell-specific regulation of human growth hormone (hGH) chorionic somatomammotropin (hCS) gene. The pituitary hGH-1 placental hCS-1, hCS-2, hGH-2 genes are unique in primates because they have evolved very recently maintained ∼95% nucleotide sequence identity. Consequently, form a particularly interesting gene family for study regulatory mechanisms may represent an important set that played role primate evolution. Both hCS found maternal circulation their concentrations increase throughout pregnancy, reaching respective maxima near term. CS appears to both lactogenic somatogenic effects. not primary mammary development individuals appear normal breast lactation isolated deficiencies CS, or GH, prolactin. control GH expression by cyclic adenosine monophosphate anterior somatotroph occurs through cascade mechanism initiated primarily action two antagonistic hypothalamic neurohormones: Somatostatin inhibits release growth-hormone-releasing-hormone (GHRH) regulates synthesis secretion..
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