Revisiting the ventral medial nucleus of the hypothalamus: the roles of SF-1 neurons in energy homeostasis

摘要: Obesity, diabetes, and other metabolic complications are growing concerns for public health could lead to detrimental life-threating conditions. Neurons whose activities required energy glucose homeostasis found in a number of hypothalamic nuclei. In the early 20th century, ventral medial nucleus hypothalamus (VMH) was first site reported play prominent role regulation through control food intake expenditure. Recent studies using sophisticated genetic tools have further highlighted importance VMH extended our understanding physiological homeostasis. These were preceded by identification steroidogenic factor-1 (SF-1) as marker VMH. This review focuses on emerging homeostatic roles SF-1 neurons discovered use models, particularly highlighting