Serrated adenoma and colorectal cancer
作者： J. R. Jass
DOI: 10.1002/(SICI)1096-9896(199904)187:5<499::AID-PATH309>3.0.CO;2-B
关键词:
摘要: Hyperplastic polyps and serrated adenomas of the colorectum show mixed gastrointestinal differentiation, expressing both gastric (M1 or MUC5AC) intestinal (MUC2) mucins. They also share phenotype mild DNA microsatellite instability (MSI-L). Recent findings clonal genetic changes within hyperplastic fit with a pathway neoplasia, perhaps culminating in subset colorectal cancer characterized by mutator phenotype.
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