Chromosomal alterations during lymphatic and liver metastasis formation of colorectal cancer.

摘要: Comparative genomic hybridization (CGH) was used to screen colorectal carcinomas for chromosomal aberrations that are associated with metastatic phenotype. In total, 63 tumor specimens from 40 patients were investigated, comprising 30 primary tumors, 22 systemic metastases (12 liver, 6 brain, and 4 abdominal wall metastases) 11 lymph node tumors. Using statistical analysis histograms evaluate the imbalances, overrepresentations detected most frequently at 20q11.2–20q13.2, 7q11.1–7q12, 13q11.2–13q14, 16p12, 19p13, 9q34, 19q13.1–19q13.2. Deletions prominent 18q12–18q23, 4q27–4q28, 4p14, 5q21, 1p21–1p22, 21q21, 6q16–6q21, 3p12, 8p22–8p23, 9p21, 11q22, 14q13–14q21. Hematogenous showed more alterations than particularly deletions 1p, 3, 4, 5q, 10q, 14, 21q21 gains 1q, 7p, 12qter, 13, 16, 22q. Comparing liver their corresponding 2q, 8p, 9p, 11, 17q12–q21, 19, 22q often observed. The suggested different pathways of dissemination reflected by a nonrandom accumulation specific changes being responsible characteristics