Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22.
作者： Lisa A Cannon-Albright , David E Goldgar , Laurence J Meyer , Cathryn M Lewis , David E Anderson
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摘要: Linkage analysis of ten Utah kindreds and one Texas kindred with multiple cases cutaneous malignant melanoma (CMM) provided evidence that a locus for familial susceptibility is in the chromosomal region 9p13-p22. The genetic markers analyzed reside candidate on chromosome 9p21, previously implicated by presence homozygous deletions tumors germline deletion an individual eight independent melanomas. Multipoint linkage was performed between (MLM) two short tandem repeat markers, D9S126 interferon-alpha (IFNA) gene, which somatic loss tumors. An incorporating partially penetrant dominant places MLM near IFNA maximum location score 12.71. Therefore, frequently deleted 9p21 presumably contains plays critical role predisposition to melanoma.
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