Cetuximab Shows Activity in Colorectal Cancer Patients With Tumors That Do Not Express the Epidermal Growth Factor Receptor by Immunohistochemistry
作者： Ki Young Chung , Jinru Shia , Nancy E. Kemeny , Manish Shah , Gary K. Schwartz
关键词:
摘要: Purpose To establish evidence of activity, or lack thereof, cetuximab-based therapy in patients with refractory colorectal cancer tumors that do not demonstrate epidermal growth factor receptor (EGFR) expression by immunohistochemistry (IHC). Patients and Methods Pharmacy computer records were reviewed to identify all who received cetuximab at Memorial Sloan-Kettering Cancer Center a nonstudy setting during the first 3 months cetuximab's commercial availability. Medical these then had experienced failure prior irinotecan-based regimen pathology report indicating an EGFR-negative tumor IHC. Pathology slides from reference pathologist confirm EGFR negativity, computed tomography scans radiologist. Response rates reported using WHO criteria. Results Sixteen chemotherapy-refractory, ...
sci-hub.se 参考文章(25)
I. Lax, F. Bellot, R. Howk, A. Ullrich, D. Givol, J. Schlessinger, Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules. The EMBO Journal. ,vol. 8, pp. 421- 427 ,(1989) , 10.1002/J.1460-2075.1989.TB03393.X
Hideo Masui, Ian Altas, John Mendelsohn, Zhen Fan, Blockade of epidermal growth factor receptor function by bivalent and monovalent fragments of 225 anti-epidermal growth factor receptor monoclonal antibodies Cancer Research. ,vol. 53, pp. 4322- 4328 ,(1993)
Leah N. Klapper, Mark H. Kirschbaum, Michael Seta, Yosef Yarden, Biochemical and Clinical Implications of the ErbB/HER Signaling Network of Growth Factor Receptors Advances in Cancer Research. ,vol. 77, pp. 25- 79 ,(1999) , 10.1016/S0065-230X(08)60784-8
A C King, P Cuatrecasas, Resolution of high and low affinity epidermal growth factor receptors. Inhibition of high affinity component by low temperature, cycloheximide, and phorbol esters. Journal of Biological Chemistry. ,vol. 257, pp. 3053- 3060 ,(1982) , 10.1016/S0021-9258(19)81072-4
G Carpenter, S Cohen, Epidermal growth factor. Journal of Biological Chemistry. ,vol. 265, pp. 7709- 7712 ,(1972) , 10.1016/S0021-9258(19)38983-5
Pilar Garin Chesa, Francisco X. Real, Lloyd J. Old, John Mendelsohn, Myron R. Melamed, Wolfgang J. Rettig, Expression of Epidermal Growth Factor Receptor in Human Cultured Cells and Tissues: Relationship to Cell Lineage and Stage of Differentiation Cancer Research. ,vol. 46, pp. 4726- 4731 ,(1986)
Sufi Mary Thomas, Jennifer Rubin Grandis, Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation. Cancer Treatment Reviews. ,vol. 30, pp. 255- 268 ,(2004) , 10.1016/J.CTRV.2003.10.003
Henning Bier, Thomas Hoffmann, Inge Haas, Anke van Lierop, None, Anti-(epidermal growth factor) receptor monoclonal antibodies for the induction of antibody-dependent cell-mediated cytotoxicity against squamous cell carcinoma lines of the head and neck. Cancer Immunology, Immunotherapy. ,vol. 46, pp. 167- 173 ,(1998) , 10.1007/S002620050475
Samuel M. Liu, Graham Carpenter, Differential heat stress stability of epidermal growth factor receptor and erbB‐2 receptor tyrosine kinase activities Journal of Cellular Physiology. ,vol. 157, pp. 237- 242 ,(1993) , 10.1002/JCP.1041570205
Gary A. Johnson, Robert Mannel, Mahmoud Khalifa, Joan L. Walker, Mary Wren, Kyung-Whan Min, Doris M. Benbrook, Epidermal Growth Factor Receptor in Vulvar Malignancies and Its Relationship to Metastasis and Patient Survival Gynecologic Oncology. ,vol. 65, pp. 425- 429 ,(1997) , 10.1006/GYNO.1997.4660