Distribution of adoptively transferred, tumor-sensitized lymphocytes in the glioma-bearing rat.
作者： Monica R. Hazelrigg , Jerry I. Hirsch , Randall E. Merchant
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摘要: For adoptively transferred lymphocytes to exert anti-tumor effects in vivo, they must traffic or initiate the migration of endogenous immune cells site tumor. Using a rat model, we examined trafficking tumor-sensitized an intracerebral glioma. By labeling with 111Indium oxine (111In) prior intravenous injection, were able quantify relative number that traveled tumor site. There was no difference lymphocytic influx between tumor-bearing and non-tumor-bearing cerebral hemispheres 3-day glioma models. However, 7-day models, significantly greater numbers 111In-labeled resided hemisphere at 12 h post-administration. This increased more than two-fold by 24 post-adoptive transfer. fluorescent-labeled microscopy, confirmed detection radioactivity within brain truly due infiltrating lymphocytes. Adoptively found perivascular peritumoral locations. These data demonstrate target where can effect, further supporting adoptive immunotherapy as treatment for
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