Embryonic atrazine exposure alters zebrafish and human miRNAs associated with angiogenesis, cancer, and neurodevelopment.

摘要: MicroRNAs (miRNAs) are short, single-stranded RNA that regulate post-transcriptional control of mRNA translation. Knowledge on the role these critical regulators in toxicological responses increasing, but is still limited. Atrazine a herbicide used throughout Midwestern US reported to frequently contaminate potable water supplies above maximum contaminant level 3 parts per billion. suspected endocrine disrupting chemical and studies have begun investigate genetic mechanisms toxicity; however, investigating epigenetic In this study both zebrafish human miRNAs were significantly altered response an embryonic atrazine exposure 0.3, 3, or 30 ppb zebrafish. Altered known play angiogenesis, cancer, neuronal development, differentiation, maturation. Targeted analysis with genes previously identified be by revealed several targets linked cell cycle signaling. Further hsa-miRNA-126-3p, which had expression all three treatments at 72 hpf, alterations also occurred 60 hpf treatment group. Results from indicate miRNA deregulation following