Autocrine, paracrine and juxtacrine signaling by EGFR ligands
作者： Amar B. Singh , Raymond C. Harris
DOI: 10.1016/J.CELLSIG.2005.03.026
关键词:
摘要: Receptor and cytoplasmic protein tyrosine kinases play prominent roles in the control of a range cellular processes during embryonic development regulation many metabolic physiological variety tissues organs. The epidermal growth factor receptor (EGFR) is well-known versatile signal transducer that has been highly conserved evolution. It functions wide processes, including cell fate determination, proliferation, migration apoptosis. number ligands can activate EGF increased These are synthesized as membrane-anchored precursor forms later shed by metalloproteinase-dependent cleavage to generate soluble ligands. In certain circumstances membrane anchored isoforms well factors may also act biologically active ligands; therefore depending on these induce juxtacrine, autocrine, paracrine and/or endocrine signaling. this review, we discuss different ways EGFR possible biological implications.
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