Up-Regulation of Long Non-Coding RNA AB073614 Predicts a Poor Prognosis in Patients with Glioma

摘要: Dysregulated long noncoding RNAs (lncRNAs) have been found in human diseases, especially cancer. Emerging evidence indicates that dysregulated lncRNAs are implicated tumorigenesis and cancer progression. LncRNA AB073614 characterized as a new candidate lncRNA promotes the development of ovarian However, role gliomas remains unknown. The expression was detected 65 glioma tissues 13 normal brain by qRT-PCR, showing significantly up-regulated cancerous compared with (p < 0.001), it positively correlated tumor grade (I-II grades vs. III-IV grades, p = 0.013) patients. Kaplan-Meier analysis demonstrated increased contributed to poor overall survival (HR (hazard ratio) 1.952, 95%CI: 1.202-3.940, 0.0129). Further, univariate Cox regression indicated overexpression an unfavorable prognostic factor 1.997, 1.135-3.514, 0.016), regardless HR 1.902, 1.066-3.391, 0.029). Finally, after adjustment age, sex, location, multivariate suggested both highly expressed 2.606, 1.408-4.824, 0.002) high (III-IV 2.720, 1.401-5.282, 0.003) could be considered independent indicators for In conclusion, our study may identified biomarker gliomas.