Solute-solvent and solvent-solvent interactions and preferential solvation of limonin in aqueous co-solvent mixtures of methanol and acetone

摘要: Abstract Solute-solvent and solvent-solvent interactions of limonin in binary solvent mixtures methanol + water acetone + water were investigated from the solubility data by using linear solvation energy relationships concept. The variation depended mainly upon hydrogen bond basicity for methanol (1) + water (2) mixtures, cavity term acetone mixtures. preferential parameters (δx1,3) two derived means inverse Kirkwood–Buff integrals method. δx1,3 values negative water-rich but positive compositions 0.24 or 0.20 (0.25) to 1 in mole fraction acetone, respectively. It was conjecturable that hydrophobic hydration around nonpolar methyl groups played a relevant role solvation. preference could be explained terms higher basic behavior molecules interacting with proton-donor functional water.