Prostate cancer-specific alterations in erg gene expression and detection and treatment methods based on those alterations
作者： Gyorgy Petrovics , Chen Sun , Taduru Sreenath , Albert L. Dobi , Shiv K. Srivastava
DOI:
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摘要: The disclosure describes alterations in ERG gene expression. isoforms and promoter sequence of the that are involved in, or associated with, prostate cancer provided. further provides therapeutic compositions methods detecting, diagnosing, prognosing, treating cancer, including biomarkers for detecting expression two more following genes: PSA/KLK3, PMEPA1, NKX3.1, ODC1, AMD1, ERG.
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google.it 参考文章(43)
R. A. Reisfeld, S. Sell, Monoclonal antibodies and cancer therapy UCLA symposium on molecular and cellular biology. Annual meeting. 14. pp. 33- 74 ,(1985)
Mark Pohl, Leslie Picoult-Newburg, Genotyping reagents, kits and methods of use thereof ,(2000)
Christa Lechelt-Kunze, Ruth Meissner, Plant phosphomevalonate kinases ,(2001)
David Lane, Ed Harlow, Antibodies: A Laboratory Manual ,(1988)
Gyorgy Petrovics, Shiv Srivastava, Methods of Diagnosing or Treating Prostate Cancer Using the ERG Gene, Alone or in Combination with Other over or Under Expressed Genes in Prostate Cancer ,(2005)
E John Coligan, Current protocols in immunology Greene Pub. Associates and Wiley-Interscience. ,(1991)
Simchon Faigler, Alon Wasserman, Eli Mintz, Liat Mintz, Avi Shoshan, Oligonucleotide library for detecting rna transcripts and splice variants that populate a transcriptome ,(2001)
Miriam Zatovicova, Zuzanna Zavadova, Silvia Pastorekova, Jaromir Pastorek, Jan Zavada, Marta Ortova Gut, Soluble form of carbonic anhydrase IX (s-CA IX), assays to detect s-CA IX, CA IX'S coexpression with HER-2/neu/c-erbB-2, and CA IX-specific monoclonal antibodies to non-immunodominant epitopes ,(2007)
Charles Y.F. Young, Donkena K. Vanaja, Methods and compositions for diagnosis, staging and prognosis of prostate cancer ,(2004)
Alexander Olek, Christian Piepenbrock, Kurt Berlin, Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations ,(2001)