Incidence and rates of visual field progression after longitudinally measured optic disc change in glaucoma.

摘要: Objective To determine whether glaucoma patients with progressive optic disc change have subsequent visual field progression earlier and at a faster rate compared those without change. Design Prospective, longitudinal, cohort study. Participants Controls Eighty-one open-angle glaucoma. Methods Patients underwent confocal scanning laser tomography standard automated perimetry every 6 months. The complete follow-up was divided into initial periods. Two periods—first 3 years (Protocol A) first half of the total B)—were used, respective remainder being follow-up. Disc during determined liberal, moderate, or conservative criteria Topographic Change Analysis. Subsequent significant pattern deviation in ≥3 locations (criterion used Early Manifest Glaucoma Trial). As control analysis, ≥1, ≥2, locations. Main Outcome Measures Survival time to progression, rates mean (MD) change, positive negative likelihood ratios. Results median (interquartile range) 11.0 (8.0–12.0) 22 (18–24) examinations. More had changes changes. consistently shorter (protocol A, 0.8–1.7 years; protocol B, 0.3–0.7 years) prior In statistically 2.9–3.0 0.7–0.9). Similarly, either always worse MD although distributions overlapped widely. were up times more likely without, 5 without. Conclusions Longitudinally measured is predictive may be an efficacious end point for functional outcomes clinical studies trials Financial Disclosure(s) authors no proprietary commercial interest any materials discussed this article.