The Association of c-myc Rearrangements with Specific Types of Human Non-Hodgkin's Lymphomas
作者： Joannes H. J. M. Van Krieken , Philip M. Kluin
DOI: 10.3109/10428199209049793
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摘要: The function of c-myc in physiology is only partially known. Its product has DNA binding properties and plays a role the control proliferation differentiation. In general, increased expression leads to abolishment involvement mouse plasmacytomas human Burkitt's lymphoma well known: due chromosomal translocation comes under influence regulatory elements immunoglobulin genes, leading gene cells. man, translocations may occur within pool (pre) B-cells Epstein Barr virus (EBV) malaria infection with subsequent immunosuppression. Apart from these early (primary?) events lymphomagenesis, also often involved tumour progression, probably by similar mechanism. Different types are associated specific lymphoma: there differences between endemic, sporadic ileocecal as those primary extranodal large cell which progressed. These differentiation lymphoid cells point stage oncogenic event occurred.
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