Cetuximab, a Monoclonal Antibody Targeting the Epidermal Growth Factor Receptor, in Combination With Gemcitabine for Advanced Pancreatic Cancer: A Multicenter Phase II Trial
作者： Henry Q. Xiong , Arthur Rosenberg , Albert LoBuglio , William Schmidt , Robert A. Wolff
关键词: Pancreatic disease 、 Oncology 、 Gemcitabine 、 Antimetabolite 、 Surgery 、 Monoclonal 、 Epidermal growth factor receptor 、 Internal medicine 、 Cetuximab 、 Pancreatic cancer 、 Medicine 、 Chemotherapy
摘要: Purpose To determine the response rate, time to disease progression, survival duration and toxicity with combination of cetuximab gemcitabine in patients epidermal growth factor receptor (EGFR)-expressing advanced pancreatic cancer. Patients Methods measurable locally or metastatic cancer who had never received chemotherapy for their immunohistochemical evidence EGFR expression were eligible multicenter phase II trial. treated at an initial dose 400 mg/m2, followed by 250 mg/m2 weekly 7 weeks. Gemcitabine was administered 1,000 weeks, 1 week rest. In subsequent cycles, weekly, 3 weeks every 4 Results Sixty-one screened expression, 58 (95%) least 1+ staining, 41 enrolled onto Five (12.2%) achieved a par...
jco.org参考文章(35)
Buchler M, Korc M, Kobrin Ms, Yamanaka Y, Friess H, Beger Hg, Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Research. ,vol. 13, pp. 565- 569 ,(1993)
G. H. Sato, J. Mendelsohn, J. Polikoff, J. D. Sato, A. D. Le, T. Kawamoto, Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Molecular biology & medicine. ,vol. 1, pp. 511- 529 ,(1983)
Robert A. Wolff, Paul Chiao, Renato Lenzi, Peter W.T. Pisters, Jeffrey E. Lee, Nora A. JanJan, Christopher H. Crane, Douglas B. Evans, James L. Abbruzzese, Current approaches and future strategies for pancreatic carcinoma. Investigational New Drugs. ,vol. 18, pp. 43- 56 ,(2000) , 10.1023/A:1006383831045
Gordon Sato, Bonnie Wolf, Tomoyuki Kawamoto, John Mendelsohn, J. Denry Sato, Hideo Masui, Growth Inhibition of Human Tumor Cells in Athymic Mice by Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies Cancer Research. ,vol. 44, pp. 1002- 1007 ,(1984)
G N Gill, T Kawamoto, C Cochet, A Le, J D Sato, H Masui, C McLeod, J Mendelsohn, Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity. Journal of Biological Chemistry. ,vol. 259, pp. 7755- 7760 ,(1984) , 10.1016/S0021-9258(17)42857-2
H A Burris, M J Moore, J Andersen, M R Green, M L Rothenberg, M R Modiano, M C Cripps, R K Portenoy, A M Storniolo, P Tarassoff, R Nelson, F A Dorr, C D Stephens, D D Von Hoff, Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. Journal of Clinical Oncology. ,vol. 15, pp. 2403- 2413 ,(1997) , 10.1200/JCO.1997.15.6.2403
J. Baselga, D. Pfister, M.R. Cooper, R. Cohen, B. Burtness, M. Bos, G. D’Andrea, A. Seidman, L. Norton, K. Gunnett, J. Falcey, V. Anderson, H. Waksal, J. Mendelsohn, Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin Journal of Clinical Oncology. ,vol. 18, pp. 904- 914 ,(2000) , 10.1200/JCO.2000.18.4.904
Nicholas R. Lemoine, Christine M. Hughes, Claire M. Barton, Richard Poulsom, Rosemary E. Jeffery, Günter Klöppel, Peter A. Hall, William J. Gullick, The epidermal growth factor receptor in human pancreatic cancer. The Journal of Pathology. ,vol. 166, pp. 7- 12 ,(1992) , 10.1002/PATH.1711660103
Bolin Liu, Zhen Fan, The monoclonal antibody 225 activates caspase-8 and induces apoptosis through a tumor necrosis factor receptor family-independent pathway. Oncogene. ,vol. 20, pp. 3726- 3734 ,(2001) , 10.1038/SJ.ONC.1204490
Jay P. Overholser, Marie C. Prewett, Andrea T. Hooper, Harlan W. Waksal, Daniel J. Hicklin, Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice. Cancer. ,vol. 89, pp. 74- 82 ,(2000) , 10.1002/1097-0142(20000701)89:1<74::AID-CNCR11>3.0.CO;2-K