Nano-engineered flavonoids for cancer protection

摘要: Diet and environment are two critical regulators that influence an individual's epigenetic profile. Besides the anterograde signaling, mitochondria act as a key regulator of alterations in cancer either by controlling concentration cofactors, activity vital enzymes or affecting transcription NF-kappaB associated signaling molecules. As modifications major drivers aberrant gene expression, designing novel nutri-epigenomic strategies to modulate reversible will be important for effective protection. In this regard, nutraceuticals such flavonoids holds significant promise epigenome through network interconnected anti-redox mechanisms. However, low solubility, rapid metabolism poor absorption gastrointestinal tract hinder their use clinical settings. Therefore, it is imperative develop nano-engineered systems which could considerably improve targeted delivery these bioactive compounds with better efficacy pharmacokinetic properties. Concerted efforts nano-engineering using polymer, lipid complexation based approaches provide successful bench-to-bedside translation broad spectrum anti-cancer agents.