Evaluation of the epidermal growth factor receptor (EGFR) in colorectal tumours and lymph node metastases
作者： J.A McKay , L.J Murray , S Curran , V.G Ross , C Clark
DOI: 10.1016/S0959-8049(02)00234-4
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摘要: Overexpression of the epidermal growth factor receptor (EGFR) often correlates with an aggressive tumour phenotype and poor prognosis. To examine relevance EGFR in colorectal cancer, we determined expression protein 249 adenocarcinomas 42 lymph node metastases using immunohistochemistry. Moreover, investigated a (CA)(n) dinucleotide repeat polymorphism gene subset 114 tumours. High levels were observed 123/249 (49.4%) samples. carcinomas correlated differentiation grade (P=0.014). However, there no associations Dukes' stage, site, patient age or gender. did not influence survival this cancer cohort (P>or=0.05). Expression was identical paired tumours metastases, only 17/42 (40.5%) samples showing equivalent (P>0.05). The distribution alleles associated These results indicate that while overexpression is common event carcinogenesis, it does
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