Mutational analysis of gene families in human cancer
作者： Alberto Bardelli , Victor E Velculescu
DOI: 10.1016/J.GDE.2004.12.009
关键词:
摘要: The completion of the human genome project has marked a new beginning in biomedical sciences. Human cancer is genetic disease and, accordingly, field oncology been one first to be impacted by this historic revolution. Knowledge sequence and organization facilitates systematic analysis alterations underlying origin evolution tumors. Recent mutational analyses colorectal other cancers have focused on examination gene families involved signal transduction, such as kinases phosphatases. This approach successful identifying mutations variety different genes, including identification PI3KCA most commonly mutated oncogenes cancer. Such genomic already demonstrated their utility basic clinical research, are expected an important impact future diagnostic therapeutic strategies.
elsevier.com
sci-hub.se 参考文章(46)
Brian J. Druker, Imatinib as a paradigm of targeted therapies. Advances in Cancer Research. ,vol. 91, pp. 1- 30 ,(2004) , 10.1016/S0065-230X(04)91001-9
Peter Blume-Jensen, Tony Hunter, Oncogenic kinase signalling. Nature. ,vol. 411, pp. 355- 365 ,(2001) , 10.1038/35077225
T.-L. Wang, C. Rago, N. Silliman, J. Ptak, S. Markowitz, J. K. V. Willson, G. Parmigiani, K. W. Kinzler, B. Vogelstein, V. E. Velculescu, Prevalence of somatic alterations in the colorectal cancer cell genome Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 3076- 3080 ,(2002) , 10.1073/PNAS.261714699
R Simon, Diagnostic and prognostic prediction using gene expression profiles in high-dimensional microarray data. British Journal of Cancer. ,vol. 89, pp. 1599- 1604 ,(2003) , 10.1038/SJ.BJC.6601326
Harith Rajagopalan, Alberto Bardelli, Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein, Victor E. Velculescu, Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature. ,vol. 418, pp. 934- 934 ,(2002) , 10.1038/418934A
Samir Hanash, Integrated global profiling of cancer. Nature Reviews Cancer. ,vol. 4, pp. 638- 644 ,(2004) , 10.1038/NRC1414
Morgan Huse, John Kuriyan, The Conformational Plasticity of Protein Kinases Cell. ,vol. 109, pp. 275- 282 ,(2002) , 10.1016/S0092-8674(02)00741-9
Nicholas K Tonks, Benjamin G Neel, Combinatorial control of the specificity of protein tyrosine phosphatases. Current Opinion in Cell Biology. ,vol. 13, pp. 182- 195 ,(2001) , 10.1016/S0955-0674(00)00196-4
Jun Luo, William B. Isaacs, Jeffrey M. Trent, David J. Duggan, Looking beyond morphology: cancer gene expression profiling using DNA microarrays. Cancer Investigation. ,vol. 21, pp. 937- 949 ,(2003) , 10.1081/CNV-120025096
E. Premkumar Reddy, Roberta K. Reynolds, Eugenio Santos, Mariano Barbacid, A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene Nature. ,vol. 300, pp. 149- 152 ,(1982) , 10.1038/300149A0