Microbiology of surgical site infections and associated antimicrobial use among Vietnamese orthopedic and neurosurgical patients.

摘要: Objectives. To determine the pathogens associated with surgical site infections (SSIs) and describe patterns of antimicrobial use resistance in orthopedic neurosurgical patients a large university hospital Vietnam. Design. Prospective cohort study. Setting. Cho Ray Hospital, Ho Chi Minh City, Patients. All who had operations during 5-week study period. Results. Of 702 patients, 80 (11.4%) developed an SSI. The incidence SSI among was 15.2% (48 315), it 8.3% (32 387). Postoperative bacterial cultures samples from sites were performed for 55 (68.8%) SSI; 68 wound swab specimens 10 cerebrospinal fluid cultured. these 78 cultures, 60 (76.9%) positive pathogen, 15 (25%) those yielded multiple pathogens. 3 most frequently isolated Pseudomonas aeruginosa (29.5% isolates), Staphylococcus aureus (11.5% Escherichia coli (10.3% isolates). Ninety percent S. isolates methicillin resistant, 91% P. ceftazidime 38% E. cefotaxime resistant. but 1 received therapy after surgery, median duration 11 days. Commonly used antimicrobials included aminopenicillins second- third-generation cephalosporins. Two or, more agents given to 634 (90%) combination drug regimens (86%) aminoglycoside. Conclusions. Our data indicate that is high our population, main causing are gram-negative bacteria often resistant commonly antimicrobials, broad-spectrum surgery widespread, implementation interventions aimed at promoting appropriate evidence-based needed