Supratentorial Pilocytic Astrocytomas, Astrocytomas, Anaplastic Astrocytomas and Glioblastomas are Characterized by a Differential Expression of S100 Proteins
作者： Isabelle Camby , Nathalie Nagy , Maria-Beatriz Lopes , Beat W. Schäfer , Claude-Alain Maurage
DOI: 10.1111/J.1750-3639.1999.TB00205.X
关键词:
摘要: The levels of expression the S100A1, S100A2, S100A3, S100A4, S100A5, S100A6 and S100B proteins were immunohistochemically assayed quantitatively determined in a series 95 astrocytic tumors including 26 World Health Organization (WHO) grade I (pilocytic astrocytomas), 23 WHO II (astrocytomas), 25 III (anaplastic astrocytomas) 21 IV (glioblastomas) cases. level immunohistochemical S100 was solid tumor tissue (tumor mass). In addition twenty blood vessel walls their corresponding perivascular astrocytes also for 10 cases chosen at random from each four histopathological groups. data showed modifications S100A3 protein expression; these clearly identified pilocytic astrocytomas II-IV as distinct biological group. Modifications enabled clear distinction to be made between low (WHO II) high IV) tumors. Very significant occurred S100A1 (and, lesser extent, S100A4 proteins) relation increasing malignancy. While S100A5 significantly expressed all (but without any malignancy), S100A2 never These thus indicate that several play major roles human
ulb.ac.be
sci-hub.se 参考文章(78)
Edward G. Shaw, Bernd W. Scheithauer, Judith R. O'Fallon, Supratentorial gliomas: a comparative study by grade and histologic type. Journal of Neuro-oncology. ,vol. 31, pp. 273- 278 ,(1997) , 10.1023/A:1005715703598
B Calabretta, R Battini, L Kaczmarek, J K de Riel, R Baserga, Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein. Journal of Biological Chemistry. ,vol. 261, pp. 12628- 12632 ,(1986) , 10.1016/S0021-9258(18)67137-6
Christine Decaestecker, Jacques Brotchi, Isabelle Camby, Sandrine Rorive, Katja Rombaut, Benoît Pirotte, Isabelle Salmon, Robert Kiss, Jules Haot, Jean Lambert Pasteels, Stereotactic biopsies from astrocytic tumors. Diagnostic information contributed by the quantitative chromatin pattern description. Analytical and Quantitative Cytology and Histology. ,vol. 17, pp. 332- 343 ,(1995)
R. Donato, Perspectives in S-100 protein biology Cell Calcium. ,vol. 12, pp. 713- 726 ,(1991) , 10.1016/0143-4160(91)90040-L
G Reifenberger, K Ichimura, V P Collins, E E Schmidt, CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Research. ,vol. 54, pp. 6321- 6324 ,(1994)
Jin Jen, J Wade Harper, Sandra H Bigner, Darell D Bigner, Nickolas Papadopoulos, Sanford Markowitz, James KV Willson, Kenneth W Kinzler, Bert Vogelstein, None, Deletion of p16 and p15 Genes in Brain Tumors Cancer Research. ,vol. 54, pp. 6353- 6358 ,(1994)
L C Murphy, L J Murphy, D Tsuyuki, M L Duckworth, R P Shiu, Cloning and characterization of a cDNA encoding a highly conserved, putative calcium binding protein, identified by an anti-prolactin receptor antiserum. Journal of Biological Chemistry. ,vol. 263, pp. 2397- 2401 ,(1988) , 10.1016/S0021-9258(18)69220-8
R. Bianchi, I. Giambanco, R. Donato, S-100 protein, but not calmodulin, binds to the glial fibrillary acidic protein and inhibits its polymerization in a Ca(2+)-dependent manner. Journal of Biological Chemistry. ,vol. 268, pp. 12669- 12674 ,(1993) , 10.1016/S0021-9258(18)31440-6
Claus W Heizmann, Jos A Cox, New perspectives on S100 proteins: a multi-functional Ca 2+ -, Zn 2+ - and Cu 2+ -binding protein family Biometals. ,vol. 11, pp. 383- 397 ,(1998) , 10.1023/A:1009212521172
Christine Decaestecker, Jean-Valéry Berthe, André Danguy, Laurence Gordower, Isabelle Salmon, Robert Kiss, Denis Goldschmidt, Jean Lambert Pasteels, Myriam Remmelink, The contribution of image cytometry and artificial intelligence-related methods of numerical data analysis for adipose tumor histopathologic classification Laboratory Investigation. ,vol. 75, pp. 295- 306 ,(1996)