miR-125b Inhibitor May Enhance the Invasion-Prevention Activity of Temozolomide in Glioblastoma Stem Cells by Targeting PIAS3
作者： Lei Shi , Yi Wan , Guan Sun , Shuguang Zhang , Zhimin Wang
DOI: 10.1007/S40259-013-0053-2
关键词:
摘要: Background Temozolomide, an alkylating agent, is a promising chemotherapeutic agent for treating glioblastoma. Although chemotherapy with temozolomide may restrain tumor growth some months, invariable recurrence suggests that cancer stem cells maintaining these tumors persist. Previous research has shown can inhibit the proliferation of human glioblastoma (GSCs); however, no focused on invasion GSCs, which important factor recurrence. Accumulating evidence indicates microRNA (miR)-125b over-expression in GSCs increase their invasiveness.
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