BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency.

摘要: Genes from the RAF family are Ras-regulated kinases involved in growth cellular responses. Recently, a V599E hotspot mutation within BRAF gene was reported high percentage of colorectal tumors and significantly associated to defective mismatch repair (MMR). Additionally, mutations were described only K-Ras-negative colon carcinomas, suggesting that BRAF/K-Ras activating might be alternative genetic events cancer. We have addressed what extent tumorigenic-positive selection exerted by seen MMR-deficient also tumorigenesis gastric Accordingly, detected 34% (25/74) 5% (7/142) MMR-proficient cases (P=0.0001). All found MSI corresponded previously V599E. Two D593K K600E additional three MSS cases. However, one 124 none 37 tumors, clearly not tumorigenesis. Nonetheless, incidence K-Ras group (P=0.0005), activation K-Ras-dependent pathways contributes cancers with MMR deficiency. our results show evidences characterize but deficiency cancer mutator phenotype pathway.