Microsatellite instability in an animal model of mammary carcinogenesis.
作者： R Dahiya , C Lee , Z Zhu , H J Thompson
DOI: 10.3892/IJO.13.1.23
关键词:
摘要: Alterations in the length of simple repetitive genomic sequences (microsatellite instability, MSI) may characterize a distinct mechanism mammary carcinogenesis. In order to investigate whether MSI is associated with chemically-induced carcinogenesis rat, 30 microdissected carcinomas were analyzed using 27 different microsatellite markers from chromosomes 1, 3, 5, 7 and 8. DNA was extracted rat cancer adjoining microscopically normal tissues same slide, amplified by PCR, polymorphic reaction products for instability. The results this study indicate that 30% cases (9 out 30) showed instability at minimum 1 locus. Three (out only three loci or less, called MSI-L (low frequency MSI). Six four more, MSI-H (high D5Mit11 D5Mgh3 loci, five D1Mit14, D1Mgh6, D5Mgh5 D8Mgh10 had D1Mgh2, D3Mgh7 D3Mit3, D3Mgh5, D7Mgh1 two D7Mit11 locus one case D3Mgh9 these experiments suggest be an important etiological event pathophysiology
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