Targeting tumor invasion: the roles of MDA-9/Syntenin.

摘要: Introduction: Melanoma differentiation-associated gene – 9 (MDA-9)/Syntenin has become an increasingly popular focus for investigation in numerous cancertypes. Originally implicated melanoma metastasis, it diverse cellular roles and is consistently identified as a regulator of tumor invasion angiogenesis. As potential target inhibiting some the most lethal aspects cancer progression, further insight into function MDA-9/Syntenin mandatory.Areas covered: Recent literature seminal articles were reviewed to summarize latest collective understanding MDA-9/Syntenin’s role normal cancerous settings. Insights its participation developmental processes are included, functional significance N- C-terminals PDZ domains MDA-9/Syntenin. Current reports highlight clinical expression level variety cancers, often correlating directly with reduced patient survival. Also presented assessments ...