In Vivo Prediction of Vascular Susceptibility to Vascular Endothelial Growth Factor Withdrawal Magnetic Resonance Imaging of C6 Rat Glioma in Nude Mice
作者： Michal Neeman , Hagit Dafni , Rinat Abramovitch , Eitzik Smouha , Laura E. Benjamin
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摘要: One of the hallmarks tumor neovasculature is prevalence immature vessels manifested by low degree recruitment vascular mural cells such as pericytes and smooth muscle cells. This difference in architecture bed provides an important therapeutic window for inflicting tumor-selective damage. Here we demonstrate application gradient echo magnetic resonance imaging (MRI) noninvasive vivo mapping maturation, ability mature to dilate response elevated levels CO2. Histological alpha-actin staining showed a match between dilating detected MRI coated with Switchable, endothelial growth factor (VEGF)-overexpressing tumors (C6-pTET-VEGF rat glioma s.c. nude mice) displayed high function significant damage upon VEGF withdrawal. However, was restricted nondilating vessels, whereas were resistant Thus, visualization maturity prognosis obliteration induced
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