MicroRNA-192 regulates cell proliferation and cell cycle transition in acute myeloid leukemia via interaction with CCNT2.

摘要: MicroRNAs (miRNAs) are a class of small non-coding RNAs approximately 18–22 nucleotides in length, which play an important role malignant transformation. The roles miR-192 as oncogene or tumor suppressor solid tumors have been previously reported. However, little is known about the human acute myeloid leukemia. results present study indicate that significantly downregulated specimens from leukemia patients. Functional assays demonstrated overexpression NB4 and HL-60 cells inhibited cell proliferation compared with control cells, induced G0/G1 cycle arrest, differentiation, apoptosis vitro. Dual-luciferase reporter gene showed suppressed activity containing wild type 3′-UTR CCNT2, but it did not suppress mutated CCNT2. QRT-PCR Western blot expression CCNT2 cells. Exogenous attenuated arrest by Collectively, inhibits induces AML regulating