Association of epidermal growth factor receptor gene amplification with loss of chromosome 10 in human glioblastoma multiforme.

摘要: Although the loss of tumor suppressor genes and activation oncogenes have been established as two fundamental mechanisms tumorigenesis in human cancer, little is known about possible interactions between these mechanisms. Loss genetic material on chromosome 10 amplification epidermal growth factor receptor (EGFR) gene are most frequently reported abnormalities glioblastoma multiforme. In order to examine a correlation aberrations, authors studied 106 gliomas (58 glioblastomas, 14 anaplastic astrocytomas, five nine pilocytic seven mixed gliomas, six oligodendrogliomas, ependymomas, one subependymoma, subependymal giant-cell astrocytoma, three gangliogliomas) with Southern blot analysis for heterozygosity both arms EGFR gene. Both were restricted glioblastomas. Of 58 patients, 72% showed 38% amplification. The remaining 28% had neither nor Without exception, glioblastomas that exhibited also lost (p less than 0.001). This invariable association suggests relationship events. Moreover, presence 15 cases but without may further imply (or genes) precedes tumorigenesis.