Tissue factor expression in rheumatoid synovium: a potential role in pannus invasion of rheumatoid arthritis.

摘要: Angiogenesis, as well pannus formation within the joint, plays an important role in erosion of articular cartilage and bone pathological process rheumatoid arthritis (RA). Tissue factor (TF), essential initiator extrinsic pathway blood coagulation, is also involved angiogenesis RA progression. In present study, we used immunofluorescence confocal scanning methods to characterize TF immunolocalization synovium. We showed that positive staining could be immunolocalized synoviocytes, CD19(+) B cells CD68(+) macrophages, whereas weak or negative tissue found CD34(+) endothelial neo-vessels, CD3(+) T CD14(+) monocytes synovium tissues. Our study demonstrates a detailed local expression synovium, supports notion TF, expressed not only by synoviocytes themselves, but infiltrating invasion progression arthritis.