MiR-125b is critical for the suppression of human U251 glioma stem cell proliferation

摘要: Stem cells are unique in their ability to self-renew and maintain tissue homoeostasis by differentiating into different cell types replace aged or damaged cells. The key characteristic of the stem is its capacity divide for long periods time. MicroRNAs (miRNAs) small noncoding RNA molecules that regulate protein expression cleaving repressing translation target mRNAs. miR-125b, one neuronal miRNAs, recently was found be necessary fission bypass normal G1/S checkpoint make insensitive chemotherapy signals, which normally stop cycle at transition. Given insensitivity gliomas hypothesis glioma cause resistance drug therapy, exploring functions mechanisms miR-125b would valuable. In this study, we downregulated human U251 cells, therefore suggesting upregulation can lead growth inhibition vitro. Further research on mechanism demonstrated miR-125b-induced proliferation due arrest transition involved regulated proteins CDK6 CDC25A; overexpression decreased CDC25A expression. These findings underscore potential through CDC25A.